The primary role of Epicentre in Mbarara is to conduct high standard clinical research, with important GCP  (Good Clinical Practice) requirements, on critical public health burdens in Uganda and Africa.  To reach this objective, Epicentre collaborates with the Mbarara University of Science and Technology (MUST) and its skilled personnel. A full-time experienced research team is now based at the Epicentre Mbarara Research Base (EMRB).

In the last 10 years, Epicentre has conducted many researches on malaria. The results of those studies provided important scientific evidence for changes in malaria control policy in East Africa. More recently, Epicentre started a research program on tuberculosis in collaboration with the MUST and Mbarara National Referral Hospital. Infectious disease in children is also an important research topic developed in the EMRB.

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